| 1. | Effect of prostaglandin e2 and the tumor necrosis factor - on second messenger of lung fibroblast
对肺成纤维细胞第二信使的影响 |
| 2. | Effect of dapk carboxylic terminal peptide on tnf - inhibition of human embryonic lung fibroblast proliferation
抑制人胚肺成纤维细胞生长的影响 |
| 3. | Role of telomerase in chrysotile induced malignant transformation of normal human embryonic lung fibroblasts
温石棉诱发人胚肺细胞恶性转化中端粒酶的作用 |
| 4. | ( 2 ) so2 derivatives has significant toxicity on human embryo lung fibroblasts , the lc50 of 4h and 24h exposure is 1 . 1133 and 2 . 0070mmol / l respectively
( 2 )二氧化硫代谢衍生物对人胚肺成纤维细胞具有明显的细胞毒性作用， 4小时和24小时细胞半数存活抑制浓度lcs 。 |
| 5. | The aglycone , steviol , exhibited greater acute toxicity than stevioside in hamsters but not in rats . steviol was clearly genotoxic after metabolic activation , inducing forward mutations in bacteria and gene mutations and chromosomal aberrations in lung fibroblasts of chinese hamsters
甜菊醇经过代谢活化后，基因毒性明显，可引致细菌产生正向突变，以及使中国仓鼠的肺纤维原细胞产生基因突变和染色体变异。 |
| 6. | The aglycone , steviol , exhibited greater acute toxicity than stevioside in hamsters but not in rats . steviol was clearly genotoxic after metabolic activation , inducing forward mutations in bacteria and gene mutations and chromosomal aberrations in lung fibroblasts of chinese hamsters
甜菊醇经过代谢活化后，基因毒性明显，可引致细菌产生正向突变，以及使中国仓鼠的肺纤维原细胞产生基因突变和染色体变异。 |
| 7. | In conclusion , so2 can not only affect respiratory system , but also other organs such as spleen , liver , thymus on their histological structures and every organ performs very differently under so2 exposure . so2 derivatives has cytotoxicity both on mouse spleen cells and human embryo lung fibroblasts
说明二氧化硫代谢衍生物对人胚肺成纤维细胞和小鼠脾细胞都有一定毒性，并且在一定范围内对小鼠脾细胞具有一定的凋亡诱导作用。 |
| 8. | We also investigated the pathological changes of mouse liver , thymus and cerebrum cortex challenged by so2 inhalation by in vivo tests . we studied the apoptotic induction on mouse spleen cells and cytotoxicity of human embryo lung fibroblasts of so2 derivatives by in vitro tests . in vivo tests of sulfur dioxide inhalation showed : ( 1 ) effects on mouse lung of so2 challenge : we found no significant apoptotic changes induced by so2 inhalation but obvious pathological changes of lung with vacuolating of osmiophilic multilamellar bodies which maybe related with the decrease of surfacant and decrease of microvillus of type ii alveolar cells ; we also found thickening of part of basement lamina between type i alveolar cells and capillary endothelium cells which may inhibit the dispersion of oxygen and contribute to lung dysfunction
二氧化硫熏气染毒的体内实验结果表明，在本次实验的浓度范围内( 56mg m ~ 3 、 112mg m ~ 3 、 168mg m ~ 3低、中、高三个浓度) ： ( 1 )通过透射电镜、 dna凝胶电泳分析和流式细胞分析发现二氧化硫吸入染毒一周对小鼠肺脏没有明显的凋亡诱导作用，但通过透射电镜观察发现二氧化硫可引起肺脏明显的超微结构改变，引起型肺泡上皮细胞板层体空泡化，微绒毛减少，线粒体致密化或肿胀变性；肺泡血管内皮细胞和型肺泡上皮细胞之间基膜增厚，使氧气弥散功能出现障碍，从而降低肺功能。 |
